Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 3, Pages 972-975Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo902458g
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Funding
- Swedish Research Council, Knut
- Alice Wallenberg Foundation
- JC Kempe Foundation
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A selective synthesis of 6-brorno-8-iodo dihydro thiazolo ring-fused 2-pyridones is described. These halogenated 2-pyridones are selectively arylated by sequential Suzuki-Miyaura couplings. This approach call advantageously be used to synthesize focused libraries of substituted ring-fused 2-pyridones, a class of compounds with novel antibacterial properties.
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