Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 9, Pages 3002-3006Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo100254g
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Funding
- Singapore National Research Foundation [NRF-RF2008-05]
- Nanyang Technological University
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An in situ generated catalyst from readily available RuH(2)(PPh(3))(4), an N-heterocyclic carbene (NHC) precursor, NaH, and acetonitrile was developed. The catalyst showed high activity for the amide synthesis directly from either alcohols or aldehydes with amines. When a mixture of an alcohol and an aldehyde was reacted with an amine, both of the corresponding amides were obtained with good yields. Homogeneous Ru(0) complexes such as eta(4)-1,5-cyclooctadiene)(eta(6)-1,3,5-cyclooetatriene)-ruthenium [Ru(cod)(cot)] and Ru(3)(CO)(12) were also active in the amidation of an alcohol or an aldehyde with the help of an in situ generated NHC ligand.
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