4.7 Article

Practical Synthesis of PC190723, an Inhibitor of the Bacterial Cell Division Protein FtsZ

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 22, Pages 7946-7949

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo101720y

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Funding

  1. UC Davis
  2. UC Davis Committee on Research
  3. National Institute of Allergy and Infectious Disease [R56AI80931-01, R01AI080931-01]
  4. Bristol-Myers Squibb
  5. National GEM Consortium
  6. Proctor Gamble

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A high-yielding and practical synthesis of the bacterial cell division inhibitor PC190723 is described The synthesis is completed in a longest linear sequence of five steps from commercially available starting materials and can be readily executed on a multigram scale

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