Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 24, Pages 8654-8657Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo1014504
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Funding
- Medicines for Malaria Venture (MMV)
- Florida Center of Excellence for Biomolecular Identification and Targeted Therapeutics (FCoE-BITT)
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A divergent route was developed to access 3-iodo- and 6-chloro-3-iodo-4(1H)-quinolones for further elaboration via mono and/or sequential Suzuki-Miyaura cross-coupling to generate novel and medicinally important 4(1H)-quinolones. Copper- and palladium-catalyzed cyanations were used to functionalize the 4-quinolone core further.
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