A Strategy to Synthesize Taxol Side Chain and (-)-epi Cytoxazone via Chiral Bronsted Acid-Rh2(OAc)4 Co-catalyzed Enantioselective Three-Component Reactions

A new approach to synthesize optically active beta-amino-alpha-hydroxyl acid derivatives via chiral Bronsted (OAc)(4) cocatalyzed three-component reactions of diazo acetates with alcohols and imines is reported. A matched reaction system was identified to give the products in moderate diastereoselectivity and good enantioselectivity. Application of this methodology is demonstrated in the efficient synthesis of a taxol side chain and (-)-epi-cytoxazone.