4.7 Article

Palladium-Catalyzed Alkoxylation of N-Methoxybenzamides via Direct sp2 C-H Bond Activation

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 2, Pages 476-479

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo902139b

Keywords

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Funding

  1. National Natural Science Foundation of China [20772117]
  2. National Basic Research Program of China [2006CB922003]

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The palladium-catalyzed ortho-alkoxylation of N-methoxybenzamides has been demonstrated. With the CON-HOMe group as a directing group, the aromatic C-H bond can be functionalized efficiently to generate ortho-alkoxylated derivatives in moderate to good yields.

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