Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 20, Pages 7037-7040Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo101675f
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Funding
- Natural Science Foundation of China [20872112, 20972114]
- Zhejang Provincial Natural Science Foundation of China [Y407116]
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Copper-catalyzed double thiolation reaction of 1.4-dihildes with sulfides has been developed for selectively synthesizing 2-trifluoromethyl benzothmphenes and benzothitizoles In the presence of CuI, a variety of 2-halo-1-(2-haloanyl)-3.3.3-trifluoropropylenes smoothily underwent the thiolation annulation with Na2S to afford 2-trifluoromethyl benzothiophenes in moderate to good yields Moreover. the conditions are compatible with N-(2-haloaryl)trifluoroacetimidoyl chlorides in the presence of NaHS and K3PO: leading to 2-trifluoromethyl benzothiazoles
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