Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 22, Pages 7936-7938Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo101685d
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Funding
- National Natural Science Foundation of China [20972083]
- Chinese 863 Project [2007AA02Z160]
- Key Subject Foundation from Beijing Department of Education [XK100030514]
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A simple and efficient copper-catalyzed approach to quinazoline derivatives has been developed, and the protocol uses readily available substituted (2-bromophenyl)methylamines and amides as the starting materials, and the cascade reactions were performed under air via sequential Ullmann-type coupling and aerobic oxidation without addition of any ligand or additive The present method provides a convenient and practical strategy for synthesis of quinazoline derivatives
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