4.7 Article

Selective Synthesis of Either Isoindole- or Isoindoline-1-carboxylic Acid Esters by Pd(0)-Catalyzed Enolate Arylation

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 18, Pages 6267-6270

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo101054j

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Funding

  1. MEC (Spain)-FEDER [CTQ2006-00500/BQU, CTQ2009-07175]

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Two efficient palladium-catalyzed intramolecular alpha-arylation reactions of alpha-amino acid esters have been developed that allow either 1-isoindolecarboxylic acid esters or the corresponding isoindolines to be selectively synthesized simply by a slight change of reaction conditions.

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