4.7 Article

Highly Efficient Access to Iminoisocoumarins and alpha-Iminopyrones via AgOTf-Catalyzed Intramolecular Enyne-Amide Cyclization

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 1, Pages 269-272

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo9023478

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Funding

  1. Science and Technology Commission of Zhejiang Province [2007C21G2010067]

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Iminoisocoumarins and alpha-iminopyrones are prepared via Sonogashira coupling and AgOTf-catalyzed 6-endo-dig O-cyclization of the enyne-amide system in dichloroethane, in one pot or stepwise, respectively.

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