4.7 Article

Enantioselective Synthesis of Indole-Fused Dihydropyranones via Catalytic Cycloaddition of Ketenes and 3-Alkylenyloxindoles

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 20, Pages 6973-6976

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo101318u

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Funding

  1. National Science Foundation of China [20872143, 20932008]
  2. Ministry of Science and Technology of China [2009ZX09501-018]
  3. Chinese Academy of Sciences

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Chiral N-heterocyclic carbenes were found to be efficient catalysts for the formal [4+2] cycloaddition reaction of alkyl(aryl)ketenes and 3-alkylenyloxindoles to give the corresponding 3 4-dihydropyrano[2,3-b]indol-2-ones in excellent yields with good diastero- and enantioselectivites in excellent

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