Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 23, Pages 7967-7989Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo101606g
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Funding
- ACS Arthur C. Cope Scholar Award
- National Institutes of Health [GM53386, GM55600, AG18933]
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In this Perspective, I outline my group's research involving the chemical syntheses of medicinally important natural products, exploration of their bioactivity, and the development of new asymmetric carbon-carbon bond-forming reactions. This paper also highlights our approach to molecular design and synthesis of conceptually novel inhibitors against target proteins involved in the pathogenesis of human diseases, including AIDS and Alzheimer's disease.
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