4.7 Article

Synthesis of 7-Aza-5-deazapurine Analogues via Copper(I)-Catalyzed Hydroamination of Alkynes and 1-Iodoalkynes

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 24, Pages 8662-8665

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo1016376

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Funding

  1. National Institute of General Medical Sciences, National Institutes of Health [GM087620]
  2. Direct For Mathematical & Physical Scien
  3. Division Of Chemistry [0848982] Funding Source: National Science Foundation

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A new method for the synthesis of dihydroimidazo[1,2-a]-[1,3,5]triazin-4(611)-ones via copper(I)-catalyzed hydro-amination was developed. In addition, for the first time, iodoalkynes were shown to participate in the copper(I)catalyzed intramolecular hydroamination reaction with exclusive formation of E-isomers.

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