4.7 Article

Fluorocyanation of Enamines

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 15, Pages 5367-5370

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo1008993

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Funding

  1. Russian Academy of Sciences
  2. Federal program Scientific and educational personnel of innovative Russia [02.740.11.0258]

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A method for the fluorocyanation of enamines has been described. The reaction involves fluorination of the electron rich double bond with N-F reagent (Selectfluor or NFSI) accompanied by trapping of beta-fluoroiminium cationic intermediate with cyanide nucleophile.

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