4.7 Article

A Highly Convergent Synthesis of Tricyclic N-Heterocycles Coupling an Ugi Reaction with a Tandem SN2′-Heck Double Cyclization

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 15, Pages 5134-5143

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo100859y

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Funding

  1. University of Genova
  2. MIUR
  3. Fondazione S. Paolo

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A small library of natural product-like compounds has been assembled by coupling an Ugi multicomponent reaction with two postcondensation transformations, carried out in one-pot fashion: a S(N)2' cyclization followed by an intramolecular Heck reaction.

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