Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 3, Pages 945-947Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo902159z
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2,2,2-Ti-ifluoro- and trichloroethyl imidates, which are easily prepared by reaction of a nitrile and a trihaloethanol in the presence of HCl, have proven to be excellent reagents for the preparation of amidines under mild reaction conditions. Depending on the nature of the ne nucleophile, the imidates call react either as the free-base or the hydrochloride salt in a telescoped process. In several cases, the p-bromobenzoate salt of the desired product was directly isolated from the reaction mixture.
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