Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 17, Pages 5994-6000Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo101401z
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- DFG
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The Pd-catalyzed intramolecular alpha-arylation of amides is applied to the synthesis of functionalized spirooxindoles. The substrate scope is evaluated, and the reaction is demonstrated to be useful for the assembly of spirooxindole natural products and derivatives thereof. As an application, a new synthesis of horsfiline 1 is presented, giving the natural product in only 4 steps from commercially available amino acid 12.
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