Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 19, Pages 6402-6410Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo100691y
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- Centro Interdipartimentale di Metodologie Chimico-Fisiche (CIMCF), University of Napoli Federico II
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A novel route to 2',3'-dideoxy-beta-L-erythro-hexopyranosyl nucleosides equipped with a 1'-(N-6-benzoyl-adenin-9-yl) or a 1'-(thymin-l-yl) moiety has been developed. Synthesis of the enantiopure sugar moiety was carried out by a de novo approach based on a domino reaction as the key step. N-Glycosidation was explored via either nucleobase-transfer mechanism (B = T) or in situ anomerization (B = A or T), affording target nucleosides with high overall stereoselectivity.
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