4.7 Article

Six-Component Reactions for the Stereoselective Synthesis of 3-Arylidene-2-oxindoles via Sequential One-Pot Ugi/Heck Carbocyclization/Sonogashira/Nucleophilic Addition

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 9, Pages 2806-2812

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo902713x

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Funding

  1. Alexander von Humboldt foundation
  2. Kimia Exir Company

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An efficient palladium-catalyzed protocol for the synthesis of 3-arylidene-2-oxindoles has been developed. In this approach, a sequential one-pot six-component reaction via Ugi/Heck carbocyclization/Sonogashira/nucleophilic addition was used for the synthesis of the desired skeleton.

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