Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 19, Pages 6693-6695Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo101077g
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- GSK Women in Science Program
- NOESY
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The rapid synthesis of 3,3-pyrrolidinyl-spirooxindole cores from readily available cyclopropyl spirooxindoles and commercially available aldehydes, amines, and sulfonamides is reported. This general procedure utilizes microwave heating to access a biologically privileged scaffold in an efficient route amenable to library population.
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