Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 24, Pages 8658-8661Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo101519t
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Funding
- ELKE of University of Crete [RG2752]
- Greek National Scholarships Foundation (IKY)
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A biocatalytic cascade reaction was designed for the stereoselective synthesis of optically pure 2-alkyl-1,3-diols employing two enzymes. The cascade process consists of two consecutive steps: a stereoselective diketone reduction and a hydroxy ketone reduction. Chiral diols were formed by the addition of ketoreductases in the same vessel, in high stereoselectivity and chemical yield, without the isolation of the intermediate beta-hydroxy ketones.
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