4.7 Article

Transition-Metal-Free Homocoupling of 1-Haloalkynes: A Facile Synthesis of Symmetrical 1,3-Diynes

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 19, Pages 6700-6703

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo101216m

Keywords

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Funding

  1. National Natural Science Foundation of China [20625205, 20772034, 20932002]
  2. National Basic Research Program of China (973 Program) [2011CB808603]
  3. Ministry of Education of China [20090172110014]

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Symmetrical 1,3-diyne compounds can be easily synthesized via a transition-metal-free homocoupling reaction of 1-haloalkynes without base and oxidant. The method shows excellent functional group compatibility and high yields.

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