4.7 Article

Asymmetric Synthesis of Sphinganine and Clavaminol H

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 15, Pages 5312-5315

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo1003899

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Funding

  1. ANR

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An efficient enantioselective synthesis of sphinganine and clavaminol H is reported. These sphingoid-type bases were obtained from commercially available fatty acids using highly enantioselective Ru-catalyzed hydrogenation and organocatalytic electrophilic amination reactions to create the stereogenic centers.

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