Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 5, Pages 1764-1766Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo9025622
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- Ministry of Education, Culture, Sports, Science, and Technology, Japan
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The direct alkynylation reaction of 1,3,4-oxadiazoles with alkynyl bromides efficiently proceeds In the presence of a copper catalyst at room temperature to create the corresponding heteroaryl-alkynyl linkage in good yields. This direct coupling provides a rapid and convergent access to oxadiazole core pi-conjugated systems.
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