Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 7, Pages 2302-2308Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo100111t
Keywords
-
Categories
Funding
- Centre for Chemical Genetics [LC06077]
- Gilead Sciences, Inc. (Foster City, CA, U.S.A.)
Ask authors/readers for more resources
Intramolecular C-H arylations were employed as a key step in the synthesis of hitherto unknown fused purine systems: 13-substituted purino[8,9-f]phenanthridines and 11-substituted 5,6-dihydropurino[8,9-a]isoquinolines. The purino[8,9-f]phenanthridines were prepared in moderate yields by double C-H arylations of 9-phenylpurines with 1,2-diiodobenzene or, more efficiently, by consecutive Suzuki coupling of 9-(2-bromophenyl)purines with 2-bromophenylboronic acid followed by intramolecular C-H arylation. 5,6-Dihydropurino[8,9-a]isoquinolines were prepared in quantitative yields by intramolecular C-H arylations of 9-(2-chlorophenethyl)purines.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available