Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 12, Pages 4537-4541Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo900623c
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Addition of Grignard reagents to chiral imines derived from isatine afforded chiral, optically enriched 3-substituted 3-aminooxindoles in satisfactory yields and diastereoisomeric ratios. A general protocol is described for the addition of alkyl, alkenyl, and aryl Grignard reagents. In one case, the absolute configuration at C3 was determined and the selective N-deprotection was described, enabling further synthetic transformations of the reaction product.
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