4.7 Article

Synthesis of Tetrahydropyrans from Propargyl Alcohols and 1,1-Cyclopropanediesters: A One-Pot Ring-Opening/Conia-ene Protocol

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 21, Pages 8414-8416

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo9019122

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Funding

  1. Natural Sciences and Engineering Research Council of Canada

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Lewis acid catalyzed ring opening of 1,1-cyclopropanediesters by the hydroxyl group of a propargyl alcohol sets tip a Subsequent Conia-ene cyclization to afford Substituted tetrahydropyrans in it one-pot, high-yielding procedure.

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