4.7 Article

Birch Reductions at Room Temperature with Alkali Metals in Silica Gel (Na2K-SG(I))

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 16, Pages 5790-5792

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo900904f

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Funding

  1. SiGNa Chemistry Inc.

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Alkali metals in silica gel (the Na2K-SG(I) reagent) cleanly effect Birch reductions of substrates with at least two or more aromatic rings. The reaction conditions are alcohol-free, ammonia-free, achieve excellent yields and high selectivities at room temperature.

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