Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 8, Pages 3148-3151Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo8027533
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An efficient one-pot propargylation/cycloisomerization tandem process has been developed for the synthesis of substituted oxazole derivatives from propargylic alcohols and amides with use of p-toluenesulfonic acid monohydrate (PTSA) as a bifunctional catalyst. This method provides a rapid and efficient access to substituted oxazoles.
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