Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 21, Pages 8396-8399Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo9017765
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Funding
- National Science Foundation of China (NSFC)
- CNRS (France)
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A chiral Lewis acid catalyst was prepared by mixing 2 equiv of chiral binol-derived organophosphoric acid and 1 equiv of Et2AlCl. In the presence of a catalytic amount of [4j](2)Al(III)Cl complex (0.05 equiv), reaction between alpha-isocyanoacetamides (2) and aldehydes (3) afforded the corresponding 5-aminooxazoles (1) in good yields and enantioselectivities Complex [4j](2)Al(III)Cl isolated as a white solid displayed similar reactivity as that prepared in situ.
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