Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 3, Pages 1093-1098Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo802096q
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [20772162, 20572136]
- 863 Foundation of China [2007AA09Z448, 2006AA09Z422]
- Science Foundation of Guangdong Province, China [2007A032600001]
- Star Lake Biotechnology Co., Inc., Zhaoqing, Guangdong, China
- key Laboratory of Tropical Disease Control
- Zhongshan University
Ask authors/readers for more resources
Three metabolites, sporothrins A, B, and C (1-3), were isolated from the mangrove endophytic fungus Sporothrix sp. (#4335). Their structures were identified by the spectral data and X-ray diffractive techniques, with compound 1 showing strong inhibition of acetylcholine esterase. 1,3,6,8-Tetrahydroxynaphthalene (T4HN) was deduced as one of the precursors in the biosynthesis of 1 and 2. In a primary biosynthesis gene study, the partial gene fragment obtained with the LC1-Im/2c-Im primer pair was shown to be closely related to genes encoding T4HN synthase. The deduced protein sequences were highly homologous to the ketosynthase domains of other fungal PKS genes involved in T4HN biosynthesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available