4.7 Article

An Efficient Carbene-Catalyzed Access to 3,4-Dihydrocoumarins

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 4, Pages 1759-1762

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo802285r

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Funding

  1. Fonds der Chemischen Industrie
  2. Deutsche Forschungsgemeinschaft (DFG) [SPP 1179]

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Dihydrocoumarins play an important role as flavor and fragrance compounds and can be prepared efficiently from o-hydroxycinnamaldehydes in a mild, atom-economic N-heterocyclic carbene-catalyzed redox lactonization. Corresponding coumarins are accessible via a one-pot domino oxidation lactonization procedure in the presence of oxidants.

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