Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 19, Pages 7407-7410Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo9014276
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Funding
- Swedish Research Council
- Berzelius Center EXSELENT
- K & A Wallenberg foundation
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Chemoenzymatic dynamic kinetic resolution (DKR) via combined ruthenium and enzyme catalysis was used in the key step of a synthesis of a neonicotinoid pesticide derivative (S)-3. The DKR was carried Out under mild conditions with low catalyst loading. The method gives (S)-3 in high enantiomeric excess (98%).
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