4.7 Article

Rossinones A and B, Biologically Active Meroterpenoids from the Antarctic Ascidian, Aplidium species

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 23, Pages 9195-9198

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo901846j

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Funding

  1. Auckland Medical Research Foundation
  2. University of Auckland Research Committee
  3. University of Auckland for the award of a Doctoral Scholarship
  4. Coral Reef Foundation
  5. NIWA [C01809]

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Rossinones A (1) and B (2), biologically active meroterpene derivatives, were isolated from an Antarctic collection of the ascidian Aplidium species and structurally characterized with spectroscopic methods. The absolute configuration of 1 was deduced by using the modified Mosher method. The rossinones exhibit anti-inflammatory, antiviral and antiproliferative activities.

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