Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 5, Pages 2171-2174Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo8023889
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Funding
- Korea Science and Engineering Foundation
- Ministry of Land, Transport, and Maritime Affairs, Korea
- Ministry of Education, Science Technology
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A facile and efficient diastereoselective one-pot synthesis of polycyclic acetal-fused pyrano[3,2-c]pyrane-5(2H)-one was achieved through the annulation reaction of 2-C-formyl glycals with various 4-hydroxycoumarins and 4-hydroxy-6-methyl-2H-pyran-2-one. The asymmetric induction was significantly influenced by the C-4 stereogenic center of 2-C-formyl glycals. The resulting polycyclic acetal-fused pyranopyrones demonstrated anticancer activities.
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