Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 7, Pages 2736-2742Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo900008w
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Funding
- U.S. National Institutes of Health's International Cooperative Biodiversity Groups program [U01 TW007401]
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Bromophycolides J-Q (1-8) were isolated from extracts of the Fijian red alga Callophycus serratus and identified with 1D and 2D NMR spectroscopy and mass spectral analyses. These diterpene-benzoate macrolides represent two novel carbon skeletons and add to the 10 previously reported bromophycolides (9-18) from this alga. Among these 18 bromophycolides, several exhibited activities in the low micromolar range against the human malaria parasite Plasmodium falciparum.
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