Nickel-Catalyzed C-H Alkenylation and Alkylation of 1,3,4-Oxadiazoles with Alkynes and Styrenes

The addition reaction of 1,3,4-oxadiazoles to alkynes via C-H bond cleavage efficiently proceeds in the presence of a nickel catalyst. This direct coupling allows a facile access to alkenyl-substituted oxadiazoles. The reaction with styrenes in place of alkynes is also available to selectively afford the corresponding branched adducts.