4.7 Article

Intramolecular Imino Diels-Alder Reaction: Progress toward the Synthesis of Uncialamycin

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 17, Pages 6728-6734

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo901291t

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Funding

  1. Rennes Metropole
  2. Region Bretagne
  3. Universite de Rennes
  4. Ministere de la Recherche

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We herein described an intramolecular imino Diels-Alder reaction promoted with BF3.OEt2/DDQ affording substituted quinolines. Using this procedure, we prepared the chiral quitioline moiety of the uncialamycin, a new enediyne natural product.

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