4.7 Article

An Improved Synthesis of Pyridine-Thiazole Cores of Thiopeptide Antibiotics

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 15, Pages 5750-5753

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo900950x

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Funding

  1. University of British Columbia
  2. Canada Research Chair Program
  3. CFI
  4. NSERC
  5. CIHR
  6. MerckFrosst Canada, Ltd.

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The oxidation of 2-methylthiazoles to 2-formylthiazoles simplifies the implementation of the Bagley variant of the Bohlmann-Rahtz reaction as a key step in a concise new route to pyridine cores of thiopeptide antibiotics.

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