Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 16, Pages 6035-6041Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo9009497
Keywords
-
Categories
Funding
- Natural Sciences and Engineering Council of Canada
- Merck-Frosst Canada Ltd.
- Universite de Sherbrooke
Ask authors/readers for more resources
We describe the synthesis of (+)-aspidofractinine, the enantiomer of a naturally occurring alkaloid of the kopsane family. Key features of the synthesis include a stereospecific cyanate to isocyanate rearrangement on a chiral scaffold, a ring-closing alkene metathesis to cleave the chiral auxiliary, and a chemoselective cyclopropanation to introduce the quaternary carbon at position 7 of aspidofractinine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available