Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 9, Pages 3599-3602Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo900390d
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- EPSRC
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The Lewis base-promoted hydrosilylation of cyclic malonates provides a convenient synthesis of beta-substituted aldehydes. No over-reduction to the primary alcohol is observed as the aldehyde functionality is protected until a subsequent hydrolysis step. The utility of the method is demonstrated in a number of examples and further in the synthesis of gamma-substituted propylamines in a one-pot hydrosilylation/reductive amination process.
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