Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 21, Pages 8452-8455Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo901682p
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Funding
- National Institutes of Health [CA28824]
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An improved synthesis of the hexasaccharide M Br 1 antigen (globo-H) is reported. Enhanced efficiency in the synthesis was necessary for the scale-up production of globo-H, in order to advance globo-H-based anticancer vaccines to clinical trials. The key features of the improved synthesis include preactivation-based glycosylations and it revised iodosulfonimidation/rearrangement.
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