4.7 Article

Catalytic Staudinger-Vilarrasa Reaction for the Direct Ligation of Carboxylic Acids and Azides

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 5, Pages 2203-2206

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo802825e

Keywords

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Funding

  1. The Ministerio de Educacion y Ciencia [SAF2002-02728, CTQ-200615393]
  2. Generalitat de Catalunya [2001SGR065]

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2,2'-Dipyridyl diselenide (PySeSePy) is the catalyst or activator of choice for the direct reaction of carboxylic acids with azides and trimethylphosphine at room temperature. The mechanism of the process, which is not an aza-Wittig reaction, has been elucidated.

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