Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 5, Pages 2207-2209Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo8024797
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A scalable procedure for the conversion of nitriles to N-tert-butyl amides via the Ritter reaction was optimized employing tert-butyl acetate and acetic acid. The reaction has a broad scope for aromatic, alkyl, and alpha,beta-unsaturated nitriles.
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