Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 11, Pages 4203-4207Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo900380f
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Funding
- Waseda University [2008A059]
- Nissui Research Foundation
- Tokyo Ohka Foundation for the Promotion of Science and Technology
- JSPS [16073207]
- Grants-in-Aid for Scientific Research [16073207] Funding Source: KAKEN
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Three new antiprotozoan compounds, gracilioethers A-C (1-3), have been isolated from the marine sponge Agelas gracilis. Their structures were elucidated on the basis of spectroscopic and chemical methods. Gracilioethers A-C showed antimalarial activity against Plasmodium falciparum with IC50 values of 0.5-10 mu g/mL, whereas gracilioether B (2) also showed antileishmanial activity.
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