4.7 Article

Stereoselective Synthesis of Novel Highly Substituted Isochromanone and Isoquinolinone-Containing Exocyclic Tetrasubstituted Alkenes

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 5, Pages 2234-2237

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo802729s

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Funding

  1. Centre National de la Recherche Scientifique, Institut Curie
  2. INCa
  3. Minisere de I'Enseignement Superieur et de la Recherche for a Ph.D. Fellowship Grant

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An efficient synthetic route toward the synthesis of highly substituted arylethylidene-isoquinolinones/isochromanones is reported. The tandem carbopalladation/Suzuki-Miyaura coupling sequence stereoselectively provided various functionalized polycyclic compounds in moderate to excellent yields.

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