4.7 Article

Synthetic Studies on N-Alkoxyamines: A Mild and Broadly Applicable Route Starting from Nitroxide Radicals and Aldehydes

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 4, Pages 1567-1573

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo802403j

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Funding

  1. Ciba Research Analytics group (Coating Effects Segment)
  2. Ciba Expert Services Group, Switzerland

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A broad variety of 2,2,6,6-tetramethylpiperidine-based N-alkoxyamines were prepared in a newly found reaction. By means of a copper-catalyzed fragmentation reaction of aldehyde peroxides in the presence of TEMPO or TEMPO derivatives, N-alkoxyamines were obtained in moderate to good yields.

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