Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 1, Pages 412-414Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo802133w
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Funding
- National Natural Science Foundation of China [20572020]
- New Century Excellent Talents in University [NCET-06-0711]
- Specialized Research Fund for the Doctoral Program of Higher Education [20060542007]
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A copper/silver-catalyzed Conia-ene reaction has been developed for selectively constructing five-membered and six-membered rings. In the presence of (CuOTf)(2)center dot C6H6 and AgBF4, a variety of 2-alkynic 1,3-dicarbonyl compounds underwent the Conia-ene intramolecular reaction smoothly in moderate to good yields. It is noteworthy that both 2-phenylacetylhept-6-ynenitrile and diethyl 2-(pent-4-ynyl)-malonate are also suitable substrates under the standard conditions, and the selectivity toward endo- or exo-products depends on the substitutents at the terminal of alkynes.
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