Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 21, Pages 8343-8354Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo901761r
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Funding
- ESPRC
- Elsevier Science
- Fond Special de Recherche
- Universite Catholique de Louvain
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Isolated in 1995, the four members of the louisianin family (A, B, C and D) are simple pyridine and 2-pyridone alkaloids that display both antibacterial and anticancer activity. Herein we describe the synthesis of all four members of the louisianin family, from I conveniently prepared 1,2,4-triazine and via I common tetrasubstituted pyridine intermediate. This study includes the synthesis of louisianin B in both racemic form and is the (-)-enantiomer.
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