4.7 Article

En Route to (S)-Selective Chemoenzymatic Dynamic Kinetic Resolution of Aliphatic Amines. One-Pot KR/Racemization/KR Sequence Leading to (S)-Amides

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 7, Pages 2901-2903

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo900074w

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Funding

  1. Agence Nationale de la Recherche [ANR 06-Blan-0137]
  2. Agence Nationale de la Recherche (ANR) [ANR-06-BLAN-0137] Funding Source: Agence Nationale de la Recherche (ANR)

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A one-pot sequential process, involving a radical racemization and an enzymatic resolution, provides access to (S)-amides, from racemic amines, with ee and yields ranging from 78 to 94% and 58 to 80%, respectively.

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